The Air Zoom Pulse is elasticated and easy to get on and off, cushioned for comfort during days spent on their feet and coated with a wipe-down surface.
The sports clothing company says the shoes are made for 'everyday heroes' and were made with input from hospital workers.
It describes the footwear as 'almost a traditional clog made athletic' and will launch them next month at an unknown price, although similar ones cost upwards of £100.
Variations on the trainers' designs have also been created by children at a hospital in Oregon and some money made from those will be donated back to the hospital.
Nike said the trainers were coated to stop fluid spills soaking into them, and had an especially grippy sole to stop workers slipping.
In an unveiling of the shoes the company said: 'Nurses, for example, walk approximately four to five miles and sit for less than an hour during the course of a 12-hour shift.
'The work is physically and mentally demanding. The design for the Air Zoom Pulse tackles those challenges with simplicity in mind.
'The shoe is easy to get on and off, and equally simple to clean. The fit, cushioning and traction systems work together to secure the foot in all hospital conditions.'
Anyone who's spent time in a hospital will know many medical staff wear rubber clog-style shoes – and it probably isn't for their fashion appeal.
According to Shoes for Crews, which makes shoes especially for nurses, doctors and other professionals, posture support, cleanliness, longevity and grip are the key reasons.
Spending entire days walking around busy wards and operating theatres means shoes must be comfortable and supportive the feet, which the wide, soft shoes
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